Австралийски учени откриха ключови гени, предпазващи от рак на кръвта
Австралийски изследователи съобщиха за пробив в онкологията, като идентифицираха гени, които играят решаваща роля в защитата на организма от развитие на рак на кръвта и могат да предотвратят появата на лимфом. Резултатите са публикувани в престижното научно списание Nature Communications.
GATOR1 – новият „щит“ срещу тумори
Екипът от учени е установил, че група протеини, известни като GATOR1, функционират като мощни туморни супресори. Те блокират процесите, които водят до трансформация на нормални клетки в ракови.
В проучването е доказано, че когато определени компоненти на GATOR1 липсват, защитният механизъм на организма се разпада, позволявайки на клетките да се размножават безконтролно. Това е било потвърдено чрез изследване на сложни предклинични модели на агресивен лимфом.
Нови възможности за лечение
Учените отбелязват, че някои съществуващи лекарства могат да бъдат също толкова ефективни, защото въздействат върху същите клетъчни пътища, които регулира GATOR1. Това отваря възможност за разработването на нови целенасочени терапии срещу рак.
„Това вълнуващо откритие предоставя нова представа за развитието и разпространението на рака, което може да се превърне в основа за по-ефективни и прецизни лечения,“ заяви водещият автор, професор Марко Херолд.
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